We all have genes that decide the way in which our cells will grow and divide. Mutations occur when the genes don’t work the way they should. Mutations can be spontaneous or inherited. Every day, cells grow, divide and die in your body. Most cells grow in an orderly manner, but sometimes they grow out of control and form cancer cells. When they do this, they can form a lump or mass called a tumor and are named after the part of the body where the tumor originated from. Breast cancer originates in the breast tissue. Breast tissue is made up of glands for milk production called lobules, and the ducts that connect lobules to the nipple. Fatty, lymphatic and connective tissue makes up the rest of the breast.
WHO GETS BREAST CANCER
About 90-95% of breast cancers are caused by spontaneous mutations. The cause of these mutations are unknown. The other 5-10% of breast cancers are caused by inherited mutations. These are mutations you are born with. BRCA1 and BRCA 2 are specific mutations for genes that increase a woman’s risk of developing breast cancer and other cancers.
The older the woman, the higher the risk.
Lifetime risk is 1 in 8 women will develop breast cancer
Excluding skin cancer, breast cancer is the most common cancer among women, accounting for nearly 1 in 4 cancers diagnosed.
White women are more likely to get breast cancer than any other ethnic or racial group. African American women are more likely to die from breast cancer.
1 in 100 cases of breast cancer will occur in men.
RISK FACTORS
family or personal of history of breast or ovarian cancer. Family history of prostate cancer
starting menopause after age 55
having your first child after 35
being a female, and getting older
never having children
having an inherited mutation in BRCA1 or BRCA2 breast cancer gene
being overweight after menopause, or being obese as an adult
use of menopausal hormones including use of estrogen and estrogen plus progestin
history of breast biopsy showing atypical hyperplasia, or history of lobular carcinoma in situ
radiation exposure or frequent x-rays in youth
high bone density
early menarche
WARNING SIGNS AND SYMPTOMS TO SEE YOUR PROVIDER ABOUT
Breast cancer, when the tumor is small, does not usually produce symptoms. When it has grown to a size that can be felt, it is usually a painless mass. See your provider if you notice any of the following:
lump, or hard knot inside the breast or the underarm area
change in the size or shape of your breast
dimpling, pulling in or puckering of your skin, breast or nipple
swelling, warmth, redness or darkening of the breast
itchy, scaly rash or sore on the nipple
nipple discharge, especially if it is spontaneous or bloody
new pain in one spot that does not go away
SCREENING TESTS
Talk to your provider about which screening tests are right for you.
Mammogram-is the best screening tool to detect early breast cancer. All women age 40 and older should have a yearly mammogram. If younger than 40, with a family history of breast cancer, talk to your provider about when to start screening.
Clinical breast exam- done by your health care provider
Self Breast Exam- all women should be familiar with the feel and appearance of their breasts.
MRI (magnetic resonance imaging)- recommended for certain women at high risk for breast cancer
BRCA1 and BRCA2 analysis- genetic testing recommended for women with strong family history of breast or ovarian cancer
BREVAGen- provides a 5-year and lifetime risk assessment for women in determining breast cancer risk
PATIENT RESOURCES
www.komen.org (Susan G. Komen for the Cure)
http://www.cancer.org (American Cancer Society)
www.cancer.gov (National Cancer Institute)
http://brevagen.com (For information on BREVAGen)
www.myriadtests.com (For information on BRCA1 and BRCA2 testing)
**You too can help fight against breast cancer. Join thousands of women and men on NOVEMBER 15th in Austin for “THE RACE FOR THE CURE”. Go to www.komen.org to register.